Publications
-
Incidence and classification of
postcolonoscopy colorectal cancers in inflammatory bowel disease: A Dutch
population-based cohort study.
J Crohns Colitis. 2018 Apr 10 [Epub ahead of print].
Authors: Wintjens DSJ, Bogie RMM, van den Heuvel TRA, le Clercq CMC, Oostenbrug LE, Romberg-Camps MJL, Straathof JW, Stassen LPS, Masclee AAM, Jonkers DMAE, Sanduleanu-Dascalescu S, Pierik MJ.
-
Frequency Modulation of Transcriptional Bursting Enables Sensitive and Rapid Gene Regulation.
Cell Syst. 2018 Feb 12. pii: S2405-4712(18)30012-75
Authors: Li C, Cesbron F, Oehler M, Brunner M, Höfer T.
-
Asymmetry between Activation and Deactivation during a Transcriptional Pulse.
Cell systems. 2017 Dec 27;5(6):646-653.e5
Authors: Dunham LSS, Momiji H, Harper CV, Downton PJ, Hey K, McNamara A, Featherstone K, Spiller DG, Rand DA, Finkenstädt B, White MRH, Davis JRE
-
Xenotransplantation of human intestine into mouse abdomen or subcutaneous tissue: Novel platforms for the study of the human enteric nervous system.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. 2017 Sep 8;
Authors: Nagy N, Marsiano N, Bruckner RS, Scharl M, Gutnick MJ, Yagel S, Arciero E, Goldstein AM, Shpigel NY
-
Type three secretion system-dependent microvascular thrombosis and ischemic enteritis in human gut xenografts infected with enteropathogenic Escherichia coli.
Infection and immunity. 2017 Aug 7;
Authors: Nissim-Eliraz E, Nir E, Shoval I, Marsiano N, Nissan I, Shemesh H, Nagy N, Goldstein AM, Gutnick M, Rosenshine I, Yagel S, Shpigel NY
-
A 20-Year Temporal Change Analysis in Incidence, Presenting Phenotype and Mortality, in the Dutch IBDSL Cohort-Can Diagnostic Factors Explain the Increase in IBD Incidence?
Journal of Crohn's & colitis. 2017 Oct 1;11(10):1169-1179
Authors: van den Heuvel TRA, Jeuring SFG, Zeegers MP, van Dongen DHE, Wolters A, Masclee AAM, Hameeteman WH, Romberg-Camps MJL, Oostenbrug LE, Pierik MJ, Jonkers DM
-
Long-time analytic approximation of large stochastic oscillators: Simulation, analysis and inference.
PLoS computational biology. 2017 Jul;13(7):e1005676
Authors: Minas G, Rand DA
-
[Changes in the treatment of Crohn's disease: fewer hospitalizations, less surgery, and reduced glucocorticoid use].
Nederlands tijdschrift voor geneeskunde. 2017;161(0):D1641
Authors: Jeuring SFG, van den Heuvel TRA, Zeegers MP, Haans JJ, Romberg-Camps MJL, Oostenbrug LE, Stassen LPS, Masclee AAM, Jonkers DMAE, Pierik MJ
-
Integration of Kinase and Calcium Signaling at the Level of Chromatin Underlies Inducible Gene Activation in T Cells.
Journal of immunology (Baltimore, Md. : 1950). 2017 Oct 15;199(8):2652-2667
Authors: Brignall R, Cauchy P, Bevington SL, Gorman B, Pisco AO, Bagnall J, Boddington C, Rowe W, England H, Rich K, Schmidt L, Dyer NP, Travis MA, Ott S, Jackson DA, Cockerill PN, Paszek P
-
c-Jun N-terminal kinase 2 promotes enterocyte survival and goblet cell differentiation in the inflamed intestine.
Mucosal immunology. 2017 Sep;10(5):1211-1223
Authors: Mandi AD, Bennek E, Verdier J, Zhang K, Roubrocks S, Davis RJ, Denecke B, Gassler N, Streetz K, Kel A, Hornef M, Cubero FJ, Trautwein C, Sellge G
-
Data on master regulators and transcription factor binding sites found by upstream analysis of multi-omics data on methotrexate resistance of colon cancer.
Data in brief. 2017 Feb;10:499-504
Authors: Kel A
-
Time trends in the epidemiology and outcome of perianal fistulizing Crohn's disease in a population-based cohort.
European journal of gastroenterology & hepatology. 2017 May;29(5):595-601
Authors: Göttgens KW, Jeuring SF, Sturkenboom R, Romberg-Camps MJ, Oostenbrug LE, Jonkers DM, Stassen LP, Masclee AA, Pierik MJ, Breukink SO
-
Improvements in the Long-Term Outcome of Crohn's Disease Over the Past Two Decades and the Relation to Changes in Medical Management: Results from the Population-Based IBDSL Cohort.
The American journal of gastroenterology. 2017 Feb;112(2):325-336
Authors: Jeuring SF, van den Heuvel TR, Liu LY, Zeegers MP, Hameeteman WH, Romberg-Camps MJ, Oostenbrug LE, Masclee AA, Jonkers DM, Pierik MJ
-
Anti-inflammatory effects of infliximab in mice are independent of tumour necrosis factor α neutralization.
Clinical and experimental immunology. 2017 Feb;187(2):225-233
Authors: Assas BM, Levison SE, Little M, England H, Battrick L, Bagnall J, McLaughlin JT, Paszek P, Else KJ, Pennock JL
-
Uncoupling of mucosal gene regulation, mRNA splicing and adherent microbiota signatures in inflammatory bowel disease.
Gut. 2017 Dec;66(12):2087-2097
Authors: Häsler R, Sheibani-Tezerji R, Sinha A, Barann M, Rehman A, Esser D, Aden K, Knecht C, Brandt B, Nikolaus S, Schäuble S, Kaleta C, Franke A, Fretter C, Müller W, Hütt MT, Krawczak M, Schreiber S, Rosenstiel P
-
Generation of a Novel T Cell Specific Interleukin-1 Receptor Type 1 Conditional Knock Out Mouse Reveals Intrinsic Defects in Survival, Expansion and Cytokine Production of CD4 T Cells.
PloS one. 2016;11(8):e0161505
Authors: Mufazalov IA, Regen T, Schelmbauer C, Kuschmann J, Muratova AM, Nikolaev A, Müller W, Pinteaux E, Waisman A
-
Fenamate NSAIDs inhibit the NLRP3 inflammasome and protect against Alzheimer's disease in rodent models.
Nature communications. 2016 Aug 11;7:12504
Authors: Daniels MJ, Rivers-Auty J, Schilling T, Spencer NG, Watremez W, Fasolino V, Booth SJ, White CS, Baldwin AG, Freeman S, Wong R, Latta C, Yu S, Jackson J, Fischer N, Koziel V, Pillot T, Bagnall J, Allan SM, Paszek P, Galea J, Harte MK, Eder C, Lawrence CB, Brough D
-
Making sense of big data in health research: Towards an EU action plan.
Genome medicine. 2016 Jun 23;8(1):71
Authors: Auffray C, Balling R, Barroso I, Bencze L, Benson M, Bergeron J, Bernal-Delgado E, Blomberg N, Bock C, Conesa A, Del Signore S, Delogne C, Devilee P, Di Meglio A, Eijkemans M, Flicek P, Graf N, Grimm V, Guchelaar HJ, Guo YK, Gut IG, Hanbury A, Hanif S, Hilgers RD, Honrado Á, Hose DR, Houwing-Duistermaat J, Hubbard T, Janacek SH, Karanikas H, Kievits T, Kohler M, Kremer A, Lanfear J, Lengauer T, Maes E, Meert T, Müller W, Nickel D, Oledzki P, Pedersen B, Petkovic M, Pliakos K, Rattray M, I Màs JR, Schneider R, Sengstag T, Serra-Picamal X, Spek W, Vaas LA, van Batenburg O, Vandelaer M, Varnai P, Villoslada P, Vizcaíno JA, Wubbe JP, Zanetti G
-
Anti-food and anti-microbial IgG subclass antibodies in inflammatory bowel disease.
Scandinavian journal of gastroenterology. 2016 Dec;51(12):1453-1461
Authors: Jansen A, Mandi AD, Bennek E, Frehn L, Verdier J, Tebrügge I, Lutz H, Streetz K, Trautwein C, Sellge G
-
Signal transduction controls heterogeneous NF-κB dynamics and target gene expression through cytokine-specific refractory states.
Nature communications. 2016 Jul 6;7:12057
Authors: Adamson A, Boddington C, Downton P, Rowe W, Bagnall J, Lam C, Maya-Mendoza A, Schmidt L, Harper CV, Spiller DG, Rand DA, Jackson DA, White MR, Paszek P
-
Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis.
American journal of physiology. Gastrointestinal and liver physiology. 2016 Jun 1;310(11):G1081-90
Authors: Merga YJ, O'Hara A, Burkitt MD, Duckworth CA, Probert CS, Campbell BJ, Pritchard DM
-
Investigating IL-1β Secretion Using Real-Time Single-Cell Imaging.
Methods in molecular biology (Clifton, N.J.). 2016;1417:75-88
Authors: Diamond C, Bagnall J, Spiller DG, White MR, Mortellaro A, Paszek P, Brough D
-
Inflammasome-dependent IL-1β release depends upon membrane permeabilisation.
Cell death and differentiation. 2016 Jul;23(7):1219-31
Authors: Martín-Sánchez F, Diamond C, Zeitler M, Gomez AI, Baroja-Mazo A, Bagnall J, Spiller D, White M, Daniels MJ, Mortellaro A, Peñalver M, Paszek P, Steringer JP, Nickel W, Brough D, Pelegrín P
-
On the External Validity of Epidemiologic Data from Hospital-based IBD Cohorts.
Journal of Crohn's & colitis. 2016 Nov;10(11):1372-1373
Authors: van den Heuvel TR, Pierik MJ, Jonkers DM
-
Epidemiology and Long-term Outcome of Inflammatory Bowel Disease Diagnosed at Elderly Age-An Increasing Distinct Entity?
Inflammatory bowel diseases. 2016 Jun;22(6):1425-34
Authors: Jeuring SF, van den Heuvel TR, Zeegers MP, Hameeteman WH, Romberg-Camps MJ, Oostenbrug LE, Masclee AA, Jonkers DM, Pierik MJ
-
Colonic gene silencing using siRNA-loaded calcium phosphate/PLGA nanoparticles ameliorates intestinal inflammation in vivo.
Journal of controlled release : official journal of the Controlled Release Society. 2016 Jan 28;222:86-96
Authors: Frede A, Neuhaus B, Klopfleisch R, Walker C, Buer J, Müller W, Epple M, Westendorf AM
-
Cohort Profile: The Inflammatory Bowel Disease South Limburg Cohort (IBDSL).
International journal of epidemiology. 2017 Apr 1;46(2):e7
Authors: van den Heuvel TR, Jonkers DM, Jeuring SF, Romberg-Camps MJ, Oostenbrug LE, Zeegers MP, Masclee AA, Pierik MJ
-
Characterization of a conditional interleukin-1 receptor 1 mouse mutant using the Cre/LoxP system.
European journal of immunology. 2016 Apr;46(4):912-8
Authors: Abdulaal WH, Walker CR, Costello R, Redondo-Castro E, Mufazalov IA, Papaemmanouil A, Rothwell NJ, Allan SM, Waisman A, Pinteaux E, Müller W
-
PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.
Biochimica et biophysica acta. 2015 Oct;1853(10 Pt A):2349-60
Authors: Dammann K, Khare V, Lang M, Claudel T, Harpain F, Granofszky N, Evstatiev R, Williams JM, Pritchard DM, Watson A, Gasche C
-
Biliary Mucosal Barrier and Microbiome.
Viszeralmedizin. 2015 Jun;31(3):156-61
Authors: Verdier J, Luedde T, Sellge G
-
Quantitative dynamic imaging of immune cell signalling using lentiviral gene transfer.
Integrative biology : quantitative biosciences from nano to macro. 2015 Jun;7(6):713-25
Authors: Bagnall J, Boddington C, Boyd J, Brignall R, Rowe W, Jones NA, Schmidt L, Spiller DG, White MR, Paszek P
-
Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip.
Veterinary pathology. 2015 May;52(3):445-55
Authors: Williams JM, Duckworth CA, Burkitt MD, Watson AJ, Campbell BJ, Pritchard DM
-
Protective mucosal immunity mediated by epithelial CD1d and IL-10.
Nature. 2014 May 22;509(7501):497-502
Authors: Olszak T, Neves JF, Dowds CM, Baker K, Glickman J, Davidson NO, Lin CS, Jobin C, Brand S, Sotlar K, Wada K, Katayama K, Nakajima A, Mizuguchi H, Kawasaki K, Nagata K, Müller W, Snapper SB, Schreiber S, Kaser A, Zeissig S, Blumberg RS
-
PRR-signaling pathways: Learning from microbial tactics.
Seminars in immunology. 2015 Mar;27(2):75-84
Authors: Sellge G, Kufer TA
-
Distinct patterns of IgG and IgA against food and microbial antigens in serum and feces of patients with inflammatory bowel diseases.
PloS one. 2014;9(9):e106750
Authors: Frehn L, Jansen A, Bennek E, Mandic AD, Temizel I, Tischendorf S, Verdier J, Tacke F, Streetz K, Trautwein C, Sellge G
-
Macrophage-restricted interleukin-10 receptor deficiency, but not IL-10 deficiency, causes severe spontaneous colitis.
Immunity. 2014 May 15;40(5):720-33
Authors: Zigmond E, Bernshtein B, Friedlander G, Walker CR, Yona S, Kim KW, Brenner O, Krauthgamer R, Varol C, Müller W, Jung S
-
Paneth cells as a site of origin for intestinal inflammation.
Nature. 2013 Nov 14;503(7475):272-6
Authors: Adolph TE, Tomczak MF, Niederreiter L, Ko HJ, Böck J, Martinez-Naves E, Glickman JN, Tschurtschenthaler M, Hartwig J, Hosomi S, Flak MB, Cusick JL, Kohno K, Iwawaki T, Billmann-Born S, Raine T, Bharti R, Lucius R, Kweon MN, Marciniak SJ, Choi A, Hagen SJ, Schreiber S, Rosenstiel P, Kaser A, Blumberg RS
-
A mouse model of pathological small intestinal epithelial cell apoptosis and shedding induced by systemic administration of lipopolysaccharide.
Disease models & mechanisms. 2013 Nov;6(6):1388-99
Authors: Williams JM, Duckworth CA, Watson AJ, Frey MR, Miguel JC, Burkitt MD, Sutton R, Hughes KR, Hall LJ, Caamaño JH, Campbell BJ, Pritchard DM
2017
2016
2015
2014
2013
work packages